Real fav - X-15 "Bull".
OK- purely a research aircraft, but it did spend some time out in "space" with the ballistic flights, Joe Walker took the Bull up to 354k feet. Quite a few NASA test pilots received their astronaut wings for achieving over 50 miles up:
Joe Walker (later died colliding with a XB-70)
Bob White (who also went on to fly F-105's over Nth Vietnam after his X-15 stint)
Bob Rushworth
Joe Engle (later a Shuttle commander)
John McKay (injured in nasty X-15 crash landing)
Bill Dana (ended up running the NASA Dryden test facility)
"Pete" Knight - also took the X-15A-2 up to Mach 6.7 (last flight of this machine due to melting damage!)
Michael Adams - USAF test pilot who tragically died in X-15A-3 (hypersonic spin on re-entry followed by divergent pitch oscillations).
Neil Armstrong course went on to get his astronaut wings in another NASA program. His claim to fame with the X-15 is his "cross country" flight when he skipped off the atmosphere and just could not get the Bull heading downstairs. At one point, he thought he might have to land at LAX!
The Bull was by out and far the greatest test research rocket aircraft/spacecraft and directly lead to the development to the Space Shuttle. Further aerospace aircraft that will cruise at hypersonic speeds in the future will also benefit from this research.
OK - my Sci Fi fav is the Tardis! Why, well it's pretty small and compact, yet super roomy inside. Zips around the universe and through time at a pinch and the Doctor always seemed to have a pretty hot companion to keep him company in his journeys through time and space. To break the boredom, he got to kick some douchebag "tin cans" or dudes with paper Mache masks in the nuts every now and again - not a bad life!